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 The 1 Alcoholic Beverage That Reduces Belly Fat?

By Kevin DiDonato MS, CSCS, CES

Resveratrol, the antioxidant component of red wine and grapes, has been shown to elicit many positive health effects.

In fact, it has been shown to slow the aging process, improve symptoms associated with diabetes, and improve brain health.

Resveratrol has also been shown to mimic the effects of calorie restriction, especially when it comes to body fat loss.

Calorie restriction, in and of itself, has been shown to slow the aging process considerably and could improve weight loss results by losing body fat, mainly in the form of white adipose tissue.

Now, a study published in the American Journal of Clinical Nutrition, could show a direct association between resveratrol and body fat loss.

Let me explain…

Resveratrol and Body Fat

With obesity levels rising, everyone is trying find a way to improve weight loss results by way of calorie restriction, eating right, and exercise.

Calorie restriction has been shown to improve weight loss results by utilizing white adipose tissue as a main fuel source, which could directly impact your body fat stores.

However, some clinical studies show that Resveratrol could mimic the effects of calorie restriction in your body.

The authors of this study wanted to test and see the effects of resveratrol on fat cell biology, and to see if resveratrol effects were due to the activation of Sirt1 in your body.

The researchers tested their hypothesis on normal pre-adipocyte and adipocytes, as well as pre-adipocytes and adipocytes that were genetically altered to be missing the Sirt1 gene.

They used the cells to study differentiation (cells taking on features of the normal fat cells), glucose uptake, proliferation (rapid increase in numbers), de novo lipogenesis (the process of taking carbohydrates and converting them into fatty acids), and adipokine secretion.

Adipokines are pro-inflammatory molecules that are secreted by your fat cells.  Increased pro-inflammatory adipokines has been shown in research to increase your risk for diabetes, metabolic syndrome, and insulin and leptin resistance.

They noted that resveratrol stopped rapid increase in the pre-adipocyte cells and adipogenic differentiation (having the ability to produce and store fatty acids) in a Sirt1 dependent manner.

Also, they showed that resveratrol stimulated basal and insulin-stimulated glucose uptake.

When they looked at the process of turning dietary carbohydrates into fat (de novo lipogenesis), they showed that resveratrol was able to inhibit this process, partly due to a down-regulation of lipogenic gene expression.

The secretion of adipokines was also affected by the introduction of resveratrol.  The researchers noted that when resveratrol was introduced, the expression and the secretion of IL-6 and IL-8 was down-regulated (the adipose cells decreased the production of these cells).

They also showed that Sirt1 was only partially responsible for the regulation of resveratrol-mediated changes and adipokine secretion.

From their work, they concluded that resveratrol could influence adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities. 

Although this research is relatively new, it still needs further research in order to verify their findings. 

However, this is an encouraging study, and could pave the way for targeting resveratrol-intracellular pathways as a method to prevent, and potentially treat, obesity and obesity-related conditions.

Fat Loss and Your Health

There are millions of people around the world who are trying to lose weight to improve their health.

Increased body fat stores and fat mass could lead to the development of heart disease, diabetes, insulin resistance, and metabolic syndrome.

Many people turn to calorie restriction as a way to lose stubborn belly fat – especially white adipose tissue.

Now, according to this study, resveratrol could play a role in fat cell mass and function, which could slow the increase in body fat.

By altering your diet to include more whole foods and watching your calorie intake may improve your weight loss results, speed up your metabolism, and slow the aging process.

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Fischer-Posovsky, P.  Kukulus, V.  Tews, D.  Uterkircher, T.  Debatin, KM.  Fulda, S.  Wabitsch, M.  Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner.  Am J Clin Nutr.  2010.  Vol. 92(1):pp. pp. 5-15. doi: 10.3945/ajcn.2009.28435.